小说描写了亚哈船长为了追逐并杀死白鲸（实为白色抹香鲸）莫比·迪克，最终与白鲸同归于尽的故事。故事营造了一种让人置身海上航行、随时遭遇各种危险甚至是死亡的氛围，是作者的代表作。1956年06月27日发行的电影《白鲸记》，就是改编自这篇小说。
Few things, even in literature, can really be said to be unique — but Moby Dick is truly unlike anything written before or since. The novel is nominally about the obsessive hunt by the crazed Captain Ahab of the book’s eponymous white whale. But interspersed in that story are digressions, paradoxes, philosophical riffs on whaling and life, and a display of techniques so advanced for its time that some have referred to the 1851 Moby Dick as the first “modern” novel.
